Methylcap-Seq Reveals Novel DNA Methylation Markers for the Diagnosis and Recurrence Prediction of Bladder Cancer in a Chinese Population

@inproceedings{Zhao2012MethylcapSeqRN,
  title={Methylcap-Seq Reveals Novel DNA Methylation Markers for the Diagnosis and Recurrence Prediction of Bladder Cancer in a Chinese Population},
  author={Yangxing Zhao and Shicheng Guo and Jingfeng Sun and Zhaohui Huang and Tongyu Zhu and Hongyu Zhang and Jun Gu and Yinghua He and Wei Wang and Kelong Ma and Jina Wang and Jian Yu},
  booktitle={PloS one},
  year={2012}
}
PURPOSE There is a need to supplement or supplant the conventional diagnostic tools, namely, cystoscopy and B-type ultrasound, for bladder cancer (BC). We aimed to identify novel DNA methylation markers for BC through genome-wide profiling of BC cell lines and subsequent methylation-specific PCR (MSP) screening of clinical urine samples. EXPERIMENTAL DESIGN The methyl-DNA binding domain (MBD) capture technique, methylCap/seq, was performed to screen for specific hypermethylated CpG islands in… CONTINUE READING

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