Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance

@inproceedings{Jeyapalan2011MethylatorPO,
  title={Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance},
  author={Jennie N. Jeyapalan and Dzul Azri Mohamed Noor and S Lee and Chenrong Tan and Vanessa Appleby and John-Paul Kilday and Roger David Palmer and Edward C. Schwalbe and Steven C. Clifford and D. Walker and Matthew J Murray and Nicholas Coleman and James Christopher Nicholson and P. J. Scotting},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:Yolk sac tumours (YSTs) and germinomas are the two major pure histological subtypes of germ cell tumours. To date, the role of DNA methylation in the aetiology of this class of tumour has only been analysed in adult testicular forms and with respect to only a few genes.Methods:A bank of paediatric tumours was analysed for global methylation of LINE-1 repeat elements and global methylation of regulatory elements using GoldenGate methylation arrays.Results:Both germinomas and YSTs… CONTINUE READING