Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers

@article{Svrcek2010MethylationTD,
  title={Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers},
  author={M. Svrcek and O. Buhard and C. Colas and F. Coulet and S. Dumont and Illiasse Massaoudi and A. Lamri and R. Hamelin and J. Cosnes and C. Oliveira and R. Seruca and Marie-Pierre Gaub and M. Legrain and Ada Collura and O. Lascols and E. Tiret and Jean‐François Fl{\'e}jou and A. Duval},
  journal={Gut},
  year={2010},
  volume={59},
  pages={1516 - 1526}
}
  • M. Svrcek, O. Buhard, +15 authors A. Duval
  • Published 2010
  • Biology, Medicine
  • Gut
  • Background and aims O6-Methylguanine-DNA methyltransferase (MGMT) removes methyl adducts from O6-guanine. Known as methylation tolerance, selection for mismatch repair (MMR)-deficient cells that are unable to initiate lethal processing of O6-methylguanine-induced mismatches in DNA is observed in vitro as a consequence of MGMT deficiency. It was therefore hypothesised that an MGMT field defect may constitute a preneoplastic event for the development of MMR-deficient tumours displaying… CONTINUE READING
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