Methylation status of the SOCS 1 and JUNB genes in chronic myeloid leukemia patients

@article{Pena2009MethylationSO,
  title={Methylation status of the SOCS 1 and JUNB genes in chronic myeloid leukemia patients},
  author={M{\'a}rcia Cristina R. Pena and M. C. Pardini and V. Colturato and N. A. Pinheiro},
  journal={Revista Brasileira De Hematologia E Hemoterapia},
  year={2009},
  volume={31},
  pages={147-152}
}
Alterations in the methylation status of genes may contribute to the progression of Chronic Myeloid Leukemia (CML). In this study, the methylation status in exon2 of SOCS- 1 and promoter regions of both SOCS- 1 and JUNB were evaluated in CML patients. The methylation status of these genes was analyzed using methylation- specific Polymerase Chain Reaction (MSP) in 30 samples from CML patients, 30 samples from these same patients after hematopoietic stem cell transplantation (HSCT) and 30 samples… Expand

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