Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma.

@article{Hirasawa2006MethylationSO,
  title={Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma.},
  author={Yuichi Hirasawa and Makoto Arai and Fumio Imazeki and Motohisa Tada and Rintaro Mikata and Kenichi Fukai and Masaru Miyazaki and Takenori Ochiai and Hiromitsu Saisho and Osamu Yokosuka},
  journal={Oncology},
  year={2006},
  volume={71 1-2},
  pages={77-85}
}
BACKGROUND/AIMS To determine the clinical significance of gene promoter methylation in hepatocellular carcinoma (HCC), we examined in clinical samples the methylation status of those promoters that showed elevated activity in hepatoma cell lines after 5-aza-2'-deoxycytidine treatment. METHODS Regarding the genes with promoter hypermethylation in the cell lines, their expression levels and methylation status in HCC and non-HCC tissues were assessed by semiquantitive RT-PCR and methylation… CONTINUE READING

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