Methylation status of CpG sites in the MCP-1 promoter is correlated to serum MCP-1 in Type 2 diabetes

@article{Liu2011MethylationSO,
  title={Methylation status of CpG sites in the MCP-1 promoter is correlated to serum MCP-1 in Type 2 diabetes},
  author={Z. H. Liu and L L Chen and X Deng and H. J. Song and Yun-fei Liao and Tianshu Zeng and J Zheng and H. Q. Li},
  journal={Journal of Endocrinological Investigation},
  year={2011},
  volume={35},
  pages={585-589}
}
Aim: Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine and plays an important role in atherosclerosis of Type 2 diabetes. The aim of this study was to investigate the methylation status of CpG sites in the MCP-1 promoter in Type 2 diabetic patients and its correlation to serum MCP-1 level, and blood glucose level. Methods: The 32 patients with Type 2 diabetes and 15 healthy controls were enrolled into the study. Body mass index, blood pressure, blood lipid, blood glucose… 

Figures and Tables from this paper

Elevation of PTPN1 promoter methylation is a significant risk factor of type 2 diabetes in the Chinese population
TLDR
Investigation of the contribution of DNA methylation of the protein tyrosine phosphatase, non-receptor type 1 (PTPN1) gene to the susceptibility to type 2 diabetes (T2D) indicates that elevated PTPN 1 promoter methylation is a risk factor for T2D in the female Chinese population.
Regulatory Factor X1 Downregulation Contributes to Monocyte Chemoattractant Protein-1 Overexpression in CD14+ Monocytes via Epigenetic Mechanisms in Coronary Heart Disease
TLDR
The results indicated that RFX1 expression deficiency in CD14+ monocytes from CAD patients contributed to MCP1 overexpression via a deficiency of recruitments of HDAC1 and SUV39H1 in the M CP1 promoter, which highlighted the vital role of RFX 1 in the pathogenesis of CAD.
Effect of rich resistant starch snack on MCP- 1 promoter methylation and triglycerides levels in type 2 diabetes mellitus patients
TLDR
It is concluded that the giving of rich resistant starch snacks intervention does not affect MCP-1 promoter methylation changes significantly, and this intervention can lead to decrease plasma triglyceride levels subjects, but not statistically significant.
BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males
TLDR
Results indicated that BCL11A methylation contributed to the risk of type 2 diabetes in males and may have an effect on the development of T2D by influencing TG metabolism, and gender difference may provide new information to aid the understanding of T1D pathogenesis.
Epigenetic regulation of TNFA expression in periodontal disease.
TLDR
Although the biopsy samples represented a mixed cell population, the change in promoter methylation status in chronic periodontal disease suggested that DNA methylation may be an important regulatory mechanism in controlling TNFA transcriptional expression in periodontAL disease.
An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin
TLDR
The findings suggested that dysfunction of MAPK pathway may play important roles in the chondrocytes damage induced by T-2 toxin, which could provide new clues for understanding the potential biological mechanism of KBD cartilage damage inducedby T- 2 toxin.
DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus
TLDR
The role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells are summarized, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease.
The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus
TLDR
The role of DNA methylation, a type of epigenetic modification, in the pathogenesis of T2DM is focused on.
Genetic Variant A-2518G of the MCP-1 is not Related to Microvascular Complications of Type 2 Diabetes Mellitus in Mexican-Mestizo Subjects
TLDR
This work aimed to determine the association of the M CP-1 A-2518G genetic polymorphism and plasma levels of MCP-1 in Mexican-Mestizo subjects, with type 2 diabetes (T2DM) and microvascular complications.
...
...

References

SHOWING 1-10 OF 35 REFERENCES
CCL 2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study
Background—Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. Methods and
CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study
Background—Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. Methods and
Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study
TLDR
LINE-1 element hypomethylation is associated with higher serum VCAM-1, and the data provide new insights into epigenetic events that may accompany the development of cardiovascular disease.
Association between the A–2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus
TLDR
In a large cohort of Caucasians, the M CP-1 G–2518 gene variant was significantly and negatively correlated with plasma MCP-1 levels and the prevalence of insulin resistance and Type 2 diabetes, adding to recent evidence supporting a role for MCP -1 in pathologies associated with hyperinsulinaemia.
Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality.
TLDR
In middle-aged women, MCP-1/CCL2, leptin, and TNF-alpha-R2 were all related to biochemical risk markers of atherosclerosis and inspection of the data showed that leptin, in both the univariate and multivariate analysis, was associated with a protective effect.
Ligands of peroxisome proliferator-activated receptor inhibit homocysteine-induced DNA methylation of inducible nitric oxide synthase gene.
TLDR
It is suggested that peroxisome proliferator-activated receptor alpha/gamma ligands can down-regulate iNOS DNA methylation, and could be useful for preventing Hcy-induced atherosclerosis by repressing iN OS expression.
Association Between Plasma Monocyte Chemoattractant Protein-1 Concentration and Cardiovascular Disease Mortality in Middle-Aged Diabetic and Nondiabetic Individuals
TLDR
In middle-aged overweight/obese individuals MCP-1/CCL2 was independently associated with CVD mortality and further studies will be necessary to establish its role as a surrogate biomarker and as a potential therapeutic target.
Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984–2002
TLDR
Whereas the association of IL-8 and IP-10 with diabetes was attenuated by multivariable adjustment, high MCP-1 levels contributed to diabetes risk independently of previously described clinical, metabolic and immunological risk factors.
Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes
TLDR
In a large cohort of patients with acute coronary syndromes, an elevated baseline level of MCP-1 was associated both with traditional risk factors for atherosclerosis as well as an increased risk for death or myocardial infarction, independent of baseline variables.
...
...