Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases.

@article{Xue2003MethylationSA,
  title={Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases.},
  author={W C Xue and Hui-chen Feng and S W Tsao and Kelvin Yuen-kwong Chan and Hextan Yuen-Sheung Ngan and P M Chiu and Colin D Maccalman and Annie Nga-Yin Cheung},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2003},
  volume={13 6},
  pages={
          879-88
        }
}
The clinical significance of cadherins in gestational trophoblastic diseases (GTD) is not fully understood. In this study, the expression of E-cadherin and cadherin-11 in 12 normal placentas, 32 cases of hydatidiform mole (HM) including 15 complete HMs and 17 partial HMs, and five choriocarcinomas was investigated by immunohistochemistry and correlated with follow-up of HMs. Cases with available frozen blocks were further analyzed by western blot and semiquantitative reverse transcriptase… CONTINUE READING

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