Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.

  title={Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.},
  author={Mary E Lucas and Krista S. Crider and Doris R. Powell and Priya Kapoor-Vazirani and P M Vertino},
  journal={The Journal of biological chemistry},
  volume={284 22},
Epigenetic silencing involving the aberrant DNA methylation of promoter-associated CpG islands is one mechanism leading to the inactivation of tumor suppressor genes in human cancers. However, the molecular mechanisms underlying this event remains poorly understood. TMS1/ASC is a novel proapoptotic signaling factor that is subject to epigenetic silencing in human breast and other cancers. The TMS1 promoter is embedded within a CpG island that is unmethylated in normal cells and is spanned by… CONTINUE READING
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