Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis

@article{Yu2002MethylationPO,
  title={Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis},
  author={Jian Yu and Min Ni and J Xu and Hongyu Zhang and Baomei Gao and Jianren Gu and Jian Chen and Lisheng Zhang and Meng-chao Wu and Sushen Zhen and Jingde Zhu},
  journal={BMC Cancer},
  year={2002},
  volume={2},
  pages={29 - 29}
}
Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to success in the battle against this disease. The methylation state of C5 of the cytosine in the CpG di-nucleotide that is enriched within or near the promoter region of over 50 % of the polymerase II genes has a drastic effect on transcription of these genes. Changes in the methylation profile of… CONTINUE READING

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