Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients

@article{Li2015MethylationPO,
  title={Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients},
  author={Zibo Li and Xinwu Guo and Yepeng Wu and Shengyun Li and Jinhua Yan and Limin Peng and Zhi Xiao and Shouman Wang and Zhongping Deng and Lizhong Dai and Wenjun Yi and Kun Xia and Lili Tang and Jun Wang},
  journal={Breast Cancer Research and Treatment},
  year={2015},
  volume={149},
  pages={767-779}
}
Gene-specific methylation alterations in breast cancer have been suggested to occur early in tumorigenesis and have the potential to be used for early detection and prevention. The continuous increase in worldwide breast cancer incidences emphasizes the urgent need for identification of methylation biomarkers for early cancer detection and patient stratification. Using microfluidic PCR-based target enrichment and next-generation bisulfite sequencing technology, we analyzed methylation status of… CONTINUE READING
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Identification and characterization of locus-specific methylation patterns within novel loci undergoing hypermethylation during breast cancer pathogenesis

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