Methylation patterns in serum DNA for early identification of disseminated breast cancer

@inproceedings{Widschwendter2017MethylationPI,
  title={Methylation patterns in serum DNA for early identification of disseminated breast cancer},
  author={Martin Widschwendter and Iona C. Evans and Allison Jones and Shohreh Ghazali and Daniel Reisel and Andy Ryan and Aleksandra Gentry-Maharaj and Michal Zik{\'a}n and David Cibula and Johannes Eichner and Marianna Alunni-Fabbroni and Julian Koch and Wolfgang Janni and Tobias Paprotka and Timo Wittenberger and Usha Menon and Benjamin Wahl and Brigitte K Rack and Harri Lempi{\"a}inen},
  booktitle={Genome Medicine},
  year={2017}
}
Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We hypothesized that cell-free DNAme markers could indicate disseminated breast cancer, even in the presence of substantial quantities of background DNA. We used reduced representation bisulfite sequencing (RRBS) of 31 tissues and established serum assays based on ultra-high coverage… CONTINUE READING