Methylation of the genes for the microRNAs miR-129-2 and miR-9-1, changes in their expression, and activation of their potential target genes in clear cell renal cell carcinoma

@article{Pronina2016MethylationOT,
  title={Methylation of the genes for the microRNAs miR-129-2 and miR-9-1, changes in their expression, and activation of their potential target genes in clear cell renal cell carcinoma},
  author={Irina V. Pronina and Eugene A Klimov and Alexey M Burdennyy and Ekaterina Beresneva and Marina V Fridman and Valeria D. Ermilova and Tatiana P. Kazubskaya and Alexandr V Karpukhin and Eleonora A. Braga and Vitaly I. Loginov},
  journal={Molecular Biology},
  year={2016},
  volume={51},
  pages={61-71}
}
Methylation of promoter CpG islands and microRNA (miRNA) interactions with mRNAs of target genes are epigenetic mechanisms that play a crucial role in deregulation of gene expression and signaling pathways in tumors. Altered expression of six chromosome 3p genes (RARB(2), SEMA3B, RHOA, GPX1, NKIRAS1, and CHL1) and two miRNA genes (MIR-129-2 and MIR-9-1) was observed in primary clear cell renal cell carcinomas (ccRCCs, 31–48 samples) by RT-PCR and qPCR. Significant downregulation (p < 0.05… CONTINUE READING