Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers.

@article{Richards2011MethylationOT,
  title={Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers.},
  author={Kristy L Richards and Baili Zhang and Meng-hong Sun and Wenli Dong and Jennifer D. Churchill and Linda L. Bachinski and Charmaine D. Wilson and Keith A. Baggerly and Guosheng Yin and D. Neil Hayes and Ignacio Wistuba and Ralf Krahe},
  journal={Cancer},
  year={2011},
  volume={117 3},
  pages={606-17}
}
BACKGROUND The transcription factor TCF21 is involved in mesenchymal-to-epithelial differentiation and was shown to be aberrantly hypermethylated in lung and head and neck cancers. Because of its reported high frequency of hypermethylation in lung cancer, further characterization of the stages and types of nonsmall cell lung cancer (NSCLC) that are hypermethylated and the frequency of hypermethylation and associated "second hits" were assessed. METHODS TCF21 promoter hypermethylation in 105… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 31 references

Methylated genes as new cancer biomarkers.

European journal of cancer • 2009
View 1 Excerpt

Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2008
View 1 Excerpt

The impact of genetic markers on the diagnosis of lung cancer: a current perspective.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2007

A microRNA expression signature of human solid tumors defines cancer gene targets.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 1 Excerpt

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