Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells.

@article{Paulson2002MethylationOT,
  title={Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells.},
  author={Emily J. Paulson and Joyce D. Fingeroth and John L. Yates and Samuel H Speck},
  journal={Virology},
  year={2002},
  volume={299 1},
  pages={
          109-21
        }
}
Epstein-Barr virus (EBV) encodes multiple latency programs: a growth-transforming program (type III) latency program and restricted-latency (types I and II) programs. During type III latency, EBV expresses six nuclear antigens, all of which are encoded by a single complex transcriptional unit driven by two linked promoters, Cp and Wp, while restricted viral latency is characterized by the expression of a single nuclear antigen, EBNA1, whose expression is driven from a distinct transcription… CONTINUE READING
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