Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2

@article{Goll2006MethylationOT,
  title={Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2},
  author={M. G. Goll and F. Kirpekar and K. Maggert and J. Yoder and C. Hsieh and X. Zhang and K. Golic and S. Jacobsen and T. Bestor},
  journal={Science},
  year={2006},
  volume={311},
  pages={395 - 398}
}
The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine methyltransferases. [...] Key Result A combined genetic and biochemical approach revealed that human DNMT2 did not methylate DNA but instead methylated a small RNA; mass spectrometry showed that this RNA is aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop.Expand
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