Methylation of secreted frizzled related protein gene in acute leukemia patients in China.

@article{Shen2011MethylationOS,
  title={Methylation of secreted frizzled related protein gene in acute leukemia patients in China.},
  author={Jian-zhen Shen and Cheng-bo Xu and Hai-ying Fu and Dang-Sen Wu and Hua-rong Zhou and Li-ping Fan},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2011},
  volume={12 10},
  pages={2617-21}
}
BACKGROUND DNA methylation of CpG islands within the promoters of specific genes may play roles in tumor initiation and progression. It has been suggested such events may serve as critical check points. METHODS The present study analyzed the methylation status of CpG islands within the promoters of secreted frizzled-related proteins (SFRPs) in 87 acute leukemia (AL) patients, 20 normal controls, and four AL cell lines. 5-aza-2'- deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, was… CONTINUE READING