Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance.


BACKGROUND Gene-promoter methylation is an epigenetic mechanism of transcription inactivation. In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia. METHOD The methylation-specific polymerase chain reaction (MS-PCR) was used to analyze p15 and p16 gene methylation in 49… (More)