Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities.

@article{Lukov2005MethylationOH,
  title={Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities.},
  author={Em{\'i}lie Luk{\'a}{\vs}ov{\'a} and Zdeněk Koř{\'i}stek and Martin Falk and Stanislav Kozubek and Sergei Grigoryev and Michal Kozubek and Vladan Ondřej and Iva Kroupov{\'a}},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={77 1},
  pages={100-11}
}
We show that common heterochromatin antigenic protein markers [HP1alpha, -beta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied… CONTINUE READING

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