Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

@article{Lachner2001MethylationOH,
  title={Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins},
  author={Monika Lachner and D{\'o}nal O'Carroll and S. A. Rea and Karl Mechtler and Thomas Jenuwein},
  journal={Nature},
  year={2001},
  volume={410},
  pages={116-120}
}
Distinct modifications of histone amino termini, such as acetylation, phosphorylation and methylation, have been proposed to underlie a chromatin-based regulatory mechanism that modulates the accessibility of genetic information. In addition to histone modifications that facilitate gene activity, it is of similar importance to restrict inappropriate gene… CONTINUE READING