Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.

@article{Singh2012MethylationOG,
  title={Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.},
  author={Arpita Singh and Haitao Wang and Liana C. Silva and Chongzheng Na and Manuel Prieto and Anthony H Futerman and Chiara Luberto and Maurizio del Poeta},
  journal={Cellular microbiology},
  year={2012},
  volume={14 4},
  pages={500-16}
}
In previous studies we showed that the replication of Cryptococcus neoformans in the lung environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which synthesizes the membrane sphingolipid GlcCer from the C9-methyl ceramide. Here, we studied the effect of the mutation of the sphingolipid C9 methyltransferase gene (SMT1), which adds a methyl group to position 9 of the sphingosine backbone of ceramide. The C. neoformans Δsmt1 mutant does not make C9-methyl ceramide and… CONTINUE READING
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