Methylation of genomes and genes at the invertebrate-vertebrate boundary.

  title={Methylation of genomes and genes at the invertebrate-vertebrate boundary.},
  author={Susan Tweedie and Jane Charlton and Virginia Clark and Adrian Bird},
  journal={Molecular and cellular biology},
  volume={17 3},
Patterns of DNA methylation in animal genomes are known to vary from an apparent absence of modified bases, via methylation of a minor fraction of the genome, to genome-wide methylation. Representative genomes from 10 invertebrate phyla comprise predominantly nonmethylated DNA and (usually but not always) a minor fraction of methylated DNA. In contrast, all 27 vertebrate genomes that have been examined display genome-wide methylation. Our studies of chordate genomes suggest that the transition… CONTINUE READING

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