Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits.

@article{Peng1995MethylationOC,
  title={Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits.},
  author={Xuwen Peng and Cathy Lang and John W. Kreider},
  journal={Virus research},
  year={1995},
  volume={35 1},
  pages={101-8}
}
Transgenic rabbits carrying multiple copies of CRPV genomic DNA were described previously (Peng et al. (1993) J. Virol. 67, 1698-1701). CRPV DNA was detectable in all tissues of the transgenic rabbits, however, the transcripts of CRPV genes only were found in skin and skin tumors. Tumor development was also restricted to skin. To study the mechanism involving tissue-specific expression of CRPV genes in rabbits, cellular DNAs, isolated from different normal tissues and skin tumors, were digested… CONTINUE READING