Methylation of TFPI2 gene is frequently detected in advanced well-differentiated colorectal cancer.

@article{Hibi2010MethylationOT,
  title={Methylation of TFPI2 gene is frequently detected in advanced well-differentiated colorectal cancer.},
  author={Kenji Hibi and Tetsuhiro Goto and Yo-hei Kitamura and Kazuaki Yokomizo and Kazuma Sakuraba and Atsushi Shirahata and Hiroki Mizukami and Mitsuo Saito and Kazuyoshi Ishibashi and Gaku Kigawa and Hiroshi Nemoto and Yutaka Sanada},
  journal={Anticancer research},
  year={2010},
  volume={30 4},
  pages={1205-7}
}
BACKGROUND Recently, it has been reported that TFPI2 (tissue factor pathway inhibitor-2), a Kunitz-type serine proteinase inhibitor, is frequently methylated in human colorectal cancer using a gene expression array-based strategy. The aim of this study therefore was to examine whether the TFPI2 methylation in surgically removed colorectal cancers was correlated to the clinicopathological features. MATERIALS AND METHODS The methylation status of the TFPI2 gene was examined in primary… CONTINUE READING