Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts.

  title={Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts.},
  author={Paula Rocha Moreira and Mariana Moreira Guimar{\~a}es and Andr{\'e} Luiz Sena Guimar{\~a}es and Marina Gonçalves Diniz and Carolina Cavali{\'e}ri Gomes and Jo{\~a}o Artur Ricieri Brito and Ricardo Santiago Gomez},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={38 1},
BACKGROUND Odontogenic keratocyst (OKC) is a benign neoplasm with an aggressive clinical behavior and a high recurrence rate. Although epigenetic alterations have been reported in different tumors, these events were not investigated in OKC yet. The aim of this study was to investigate the presence of methylation in P16, P21, P27, P53 and RB1 genes in OKC tumors. METHODS Methylation-specific polymerase chain reaction (MSP) was used to evaluate the presence of methylation in 10 samples of OKCs… CONTINUE READING