Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

  title={Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia},
  author={Aroa Baraga{\~n}o Raneros and Vanesa Mart{\'i}n-Palanco and A Foncubierta Fern{\'a}ndez and Ram{\'o}n Mar{\'i}a Rodr{\'i}guez and Mario F Fraga and Carlos L{\'o}pez-Larrea and Beatriz Suarez-Alvarez},
  journal={Genes and Immunity},
Engagement of the activating receptor NKG2D (natural killer group 2 member D) with its ligands (NKG2DL) major histocompatibility complex class I related-A and -B (MICA/B), UL-16 binding protein families (ULBPs 1–6) is important to ensure the innate immunity to tumor cells. However, these cells have developed strategies to downregulate NKG2DL expression and avoid immune recognition. We demonstrate that DNA methylation can contribute to the absence of NKG2DL expression during tumor progression… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 58 references

Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses

  • J Hilpert, L Grosse-Hoves, F Grunebach, C Buechele, T Nuebling, T Raum
  • J Immunol
  • 2012

Similar Papers

Loading similar papers…