Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling

@inproceedings{Zhang2016MethylationOD,
  title={Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling},
  author={Meiying Zhang and Enqiang Linghu and Qi-min Zhan and Tao He and Baoping Cao and Malcolm Vernon Brock and James G. Herman and Rong Xiang and Mingzhou Guo},
  booktitle={Oncotarget},
  year={2016}
}
Esophageal cancer is one of the most common malignancies worldwide. DACT2 is frequently methylated in human lung, hepatic, gastric and thyroid cancers. The methylation status and function of DACT2 remain to be elucidated in human esophageal cancer. Ten esophageal cancer cell lines, 42 cases of dysplasia and 126 cases of primary esophageal cancer samples were analyzed in this study. The expression of DACT2 was detected in YES2 cells, while reduced DACT2 expression levels were found in TE8 and… CONTINUE READING

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