Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.

@article{Yang2007MethylationOC,
  title={Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.},
  author={Qiwei Yang and Colleen M. Kiernan and Yufeng Tian and Helen R. Salwen and Alexandre Chlenski and Babette A. Brumback and Wendy B London and Susan L Cohn},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 11},
  pages={3191-7}
}
PURPOSE Epigenetic aberrations have been shown to play an important role in the pathogenesis of most cancers. To investigate the clinical significance of epigenetic changes in neuroblastoma, we evaluated the relationship between clinicopathologic variables and the pattern of gene methylation in neuroblastoma cell lines and tumors. EXPERIMENTAL DESIGN Methylation-specific PCR was used to evaluate the gene methylation status of 19 genes in 14 neuroblastoma cell lines and 8 genes in 70 primary… CONTINUE READING