Methylation mediated silencing of miR-23b expression and its role in glioma stem cells.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at a post-transcriptional level. Some miRNAs harboring CGIs undergo methylation mediated silencing, a characteristic of many tumor suppressor genes. To identify such miRNAs in glioma stem cells (GSCs), we first showed that miR-23b is frequently methylated in… (More)
DOI: 10.1016/j.neulet.2012.08.055

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