Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley.

@article{Hussain2011MethylationmediatedGS,
  title={Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley.},
  author={S. Sajjad Hussain and Neha Singh and I. S. Abd-El Salam and Kapil Bandil and Manoharan Yuvaraj and Mohammad Akbar Bhat and Mohammad Muzaffar Mir and Mushtaq Ahmad Siddiqi and Ranbir Chander Sobti and Mausumi Bharadwaj and Bhudev Chandra Das},
  journal={Journal of receptor and signal transduction research},
  year={2011},
  volume={31 2},
  pages={147-56}
}
CONTEXT Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related deaths in Jammu and Kashmir. The negative regulation of tumor suppressor gene leading to change in signaling pathway is one of the major mechanisms responsible for tumorigenic transformation. OBJECTIVE In the present study, the role of silencing of suppressor of cytokine signaling-1 (SOCS-1) gene, a negative regulator of JAK/STAT pathway, was analyzed in ESCC. METHODS The expression pattern of SOCS-1 gene… CONTINUE READING