Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

@inproceedings{Polansky2010MethylationMB,
  title={Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells},
  author={Julia K. Polansky and Lisa Schreiber and Christoph Thelemann and Leif Si-Hun Ludwig and Melanie Kr{\"u}ger and Ria Baumgrass and Sascha Cording and Stefan Floess and Alf Hamann and Jochen Huehn},
  booktitle={Journal of Molecular Medicine},
  year={2010}
}
The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-shooting immune responses. However, the transcriptional regulation of Foxp3 expression remains incompletely understood. We have previously shown that epigenetic modifications in the CpG-rich Treg-specific demethylated region (TSDR) in the Foxp3 locus are… CONTINUE READING