Methylation in vivo of elongation factor EF-Tu at lysine-56 decreases the rate of tRNA-dependent GTP hydrolysis.

@article{Noort1986MethylationIV,
  title={Methylation in vivo of elongation factor EF-Tu at lysine-56 decreases the rate of tRNA-dependent GTP hydrolysis.},
  author={Johannes M. van Noort and Barend Kraal and K. M. C. Sinjorgo and Niek L. M. Persoon and E S Johanns and Leendert Bosch},
  journal={European journal of biochemistry},
  year={1986},
  volume={160 3},
  pages={557-61}
}
In this paper we show, that the in vivo methylation of the elongation factor Tu from Escherichia coli is correlated with the growth phase of the bacterium. Methylation occurs at one position only, i.e. Lys-56, and initially results in monomethylation during logarithmic growth. Upon entering the stationary phase of E. coli, monomethyllysine is gradually converted into dimethyllysine. We have undertaken an extensive comparison between the properties of the highly methylated EF-Tu and unmodified… CONTINUE READING

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