Methylation hypothesis.

  title={Methylation hypothesis.},
  author={R. Baldessarini and G. Stramentinoli and J. Lipinski},
  journal={Archives of general psychiatry},
  volume={36 3},
L-Methionine had no behavioral effects in normal humans and failed to increase concentrations of S-adenosylmethionine (methyl donor) in human or rat blood, while increasing rat liver levels more than fivefold. Methionine or S-adenosylmethionine in very high doses had almost no effect on methylation of tritiated levodopa in rodent tissues; various "methyl acceptor" molecules, including nicotinamide, guanidineacetic acid, and estradiol similarly had little effect. In rabbit lung, methionine and S… Expand
9 Citations
S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis
  • 100
5 th Amino Acid Assessment Workshop Toxicity of Methionine in Humans 1
  • 2
Biological Methylation and Drug Design
  • 115
Schizophrenia and single-carbon metabolism
  • B. Regland
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2005
  • 45
  • PDF
Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation
  • 1
The Role of One‐Carbon Metabolism in Schizophrenia and Depression
  • 84
The transmethylation and one-carbon cycle hypotheses of schizophrenia.
  • J. Smythies
  • Psychology, Medicine
  • Psychological medicine
  • 1983
  • 16
  • PDF
Biological studies of schizophrenia in Europe.
  • L. Prilipko
  • Psychology, Medicine
  • Schizophrenia bulletin
  • 1986
  • 9
  • PDF