Methylation hypothesis.

@article{Baldessarini1979MethylationH,
  title={Methylation hypothesis.},
  author={R. Baldessarini and G. Stramentinoli and J. Lipinski},
  journal={Archives of general psychiatry},
  year={1979},
  volume={36 3},
  pages={
          303-7
        }
}
L-Methionine had no behavioral effects in normal humans and failed to increase concentrations of S-adenosylmethionine (methyl donor) in human or rat blood, while increasing rat liver levels more than fivefold. Methionine or S-adenosylmethionine in very high doses had almost no effect on methylation of tritiated levodopa in rodent tissues; various "methyl acceptor" molecules, including nicotinamide, guanidineacetic acid, and estradiol similarly had little effect. In rabbit lung, methionine and S… Expand
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