Methylation-dependent silencing at the H19 imprinting control region by MeCP2.

  title={Methylation-dependent silencing at the H19 imprinting control region by MeCP2.},
  author={Robert A. Drewell and Carolyn J Goddard and Jean O. Thomas and M. Azim Surani},
  journal={Nucleic acids research},
  volume={30 5},
Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including imprinted genes. In the case of the imprinted H19 gene, a 2 kb imprinting control region (ICR) is subject to differential methylation, as it is methylated only on the silenced paternal allele. This region has previously been shown to act as a silencer element at the endogenous locus. The proteins that bind at the H19 differentially methylated domain (DMD) and mediate transcriptional silencing have… CONTINUE READING

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