Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin

@article{Temmerman2004MethylationdependentTC,
  title={Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin},
  author={St{\'e}phane T. Temmerman and K{\'e}vin Pethe and Marcela Alejandra Parra and S. Sevilla Alonso and Carine Rouanet and Thames Pickett and Annie Drowart and Anne-Sophie Debrie and Giovanni Delogu and Franco Menozzi and Christian Sergheraert and Michael James William Brennan and Françoise Mascart and Camille Locht},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={935-941}
}
Although post-translational modifications of protein antigens may be important componenets of some B cell epitopes, the determinants of T cell immunity are generally nonmodified peptides. Here we show that methylation of the Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA) by the bacterium is essential for effective T cell immunity to this antigen in infected healthy humans and in mice. Methylated HBHA provides high levels of protection against M. tuberculosis challenge in mice… CONTINUE READING
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