Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia.

@article{Tang2014MethylationAA,
  title={Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia.},
  author={Hao Tang and Caroline F. Dalton and Umarat Srisawat and Zhi Jun Zhang and Gavin Paul Reynolds},
  journal={The international journal of neuropsychopharmacology},
  year={2014},
  volume={17 4},
  pages={645-9}
}
Individual variability and inadequate response of negative symptoms are major limitations of antipsychotic treatment in schizophrenia. A functional polymorphism, rs6295, in the 5-HT1A-receptor gene (HTR1A) contributes to this variability in negative symptom response. The DNA sequence containing rs6295 is rich in cytosine methylation (CpG) sites; CpG methylation is an epigenetic factor that, like rs6295, can modify transcriptional control. To investigate whether DNA methylation influences… CONTINUE READING
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