Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma.

@article{Andersen2015MethylationassociatedSO,
  title={Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma.},
  author={Morten Tolstrup Andersen and Davide Trapani and Jesper N. Ravn and Jens Benn S{\o}rensen and Claus B{\o}gelund Andersen and Morten Grauslund and Eric Santoni-Rugiu},
  journal={Anticancer research},
  year={2015},
  volume={35 11},
  pages={
          6223-9
        }
}
BACKGROUND/AIM We recently reported that miR-126 is down-regulated in malignant pleural mesothelioma (MPM) and can be combined into a 4-microRNA-classifier that can accurately diagnose MPM with high sensitivity and specificity. Herein we analyzed the epigenetic regulation of miR-126 and its host gene EGF-like domain, multiple 7 (EGFL7). MATERIALS AND METHODS Resected formalin-fixed paraffin-embedded MPM tissues from 29 patients, 14 patient-matched non-neoplastic pleura (NNP) specimens, 5 MPM… CONTINUE READING
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