Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome.

@article{Dickstein2010MethylationAS,
  title={Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome.},
  author={Jerome Dickstein and Vitalyi Senyuk and Kavitha Premanand and Leopoldo Laricchia-Robbio and Peng Xu and Francesca Cattaneo and Raffaella Fazzina and Giuseppina Nucifora},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 21},
  pages={9783-8}
}
By expressing EVI1 in murine bone marrow (BM), we previously described a myelodysplastic syndrome (MDS) model characterized by pancytopenia, dysmegakaryopoiesis, dyserythropoiesis, and BM failure. The mice invariably died 11-14 months after BM transplantation (BMT). Here, we show that a double point mutant EVI1-(1+6Mut), unable to bind Gata1, abrogates the onset of MDS in the mouse and re-establishes normal megakaryopoiesis, erythropoiesis, BM function, and peripheral blood profiles. These… CONTINUE READING
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