Methylation and processing of ribosomal RNA in HeLa cells.

  title={Methylation and processing of ribosomal RNA in HeLa cells.},
  author={Harry E. Greenberg and Sheldon Penman},
  journal={Journal of molecular biology},
  volume={21 3},
The methylation of RNA in HeLa cells has been studied. After incorporation of radioactive methyl-labeled methionine, the cells were fractionated into cytoplasmic, nuclear, and nucleolar fractions. Methylation of high molecular weight RNA is shown to be exclusively in the 45 s ribosomal RNA precursor and takes place in the nucleolus. The methylation of the 45 s RNA apparently occurs close to the growing point of newly synthesized RNA as evidenced by the existence of methylated, partially… CONTINUE READING


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