Methylation and acetylation in nervous system development and neurodegenerative disorders

@article{Mattson2003MethylationAA,
  title={Methylation and acetylation in nervous system development and neurodegenerative disorders},
  author={Mark P. Mattson},
  journal={Ageing Research Reviews},
  year={2003},
  volume={2},
  pages={329-342}
}
The cytoarchitecture and cellular signaling mechanisms of the nervous system are complex, and this complexity is reflected at the molecular level with more genes being expressed in the nervous system than in any other tissue. Gene expression and protein function in neural cells can be regulated by methylation and acetylation. Studies of mice deficient in enzymes that control DNA methylation and of animals with a dietary deficiency of folate have established critical roles for methylation in… CONTINUE READING

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