Methylation analysis of a marsupial X-linked CpG island by bisulfite genomic sequencing.

@article{Loebel1996MethylationAO,
  title={Methylation analysis of a marsupial X-linked CpG island by bisulfite genomic sequencing.},
  author={David A. F. Loebel and Peter G. Johnston},
  journal={Genome research},
  year={1996},
  volume={6 2},
  pages={114-23}
}
Paternal X chromosome inactivation occurs in rodent extraembryonic membranes and in all tissues of marsupials. Methylation of CpG islands occurs on the inactive X in eutherians and is considered to be a stabilizing mechanism. The only previous study of a marsupial X-linked CpG island was of the G6PD gene of the Virginia opossum, in which the paternally derived allele is not completely repressed. We have cloned the 5' end of the G6PD gene from an Australian marsupial, the common wallaroo, and… CONTINUE READING