Methylation Protects miRNAs and siRNAs from a 3′-End Uridylation Activity in Arabidopsis

@article{Li2005MethylationPM,
  title={Methylation Protects miRNAs and siRNAs from a 3′-End Uridylation Activity in Arabidopsis},
  author={Junjie Li and Zhiyong Yang and Bin Yu and Jun Liu and Xuemei Chen},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={1501-1507}
}
Small RNAs of 21-25 nucleotides (nt), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), act as guide RNAs to silence target-gene expression in a sequence-specific manner. In addition to a Dicer homolog, DCL1, the biogenesis of miRNAs in Arabidopsis requires another protein, HEN1. miRNAs are reduced in abundance and increased in size in hen1 mutants. We found that HEN1 is a miRNA methyltransferase that adds a methyl group to the 3'-most nucleotide of miRNAs, but the role of miRNA… CONTINUE READING
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