Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy

  title={Methylation-Mediated Molecular Dysregulation in Clinical Oral Malignancy},
  author={Rebecca M. Towle and Cathie Garnis},
  booktitle={Journal of oncology},
Herein we provide a concise review of the state of methylation research as it pertains to clinical oral cancerous and precancerous tissues. We provide context for ongoing research efforts in this field and describe technologies that are presently being applied to analyze clinical specimens. We also discuss the various recurrent methylation changes that have been reported for oral malignancy (including those genes frequently silenced by promoter methylation and the small RNAs with activity… CONTINUE READING

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