Methylated purines in human liver DNA after probable dimethylnitrosamine poisoning.

@article{Herron1980MethylatedPI,
  title={Methylated purines in human liver DNA after probable dimethylnitrosamine poisoning.},
  author={Dan Herron and Ronald C. Shank},
  journal={Cancer research},
  year={1980},
  volume={40 9},
  pages={3116-7}
}
DNA, isolated from two samples of human liver obtained from a suspected dimethylnitrosamine poisoning, contained 1363 to 1373 micromol of 7-methylguanine per mol of guanine and 273 to 317 micromol of O6-methylguanine per mol of guanine. Liver and kidney DNA obtained from unrelated cases contained no detectable methylated purines. From the DNA methylation levels, it is estimated that the dimethylnitrosamine-poisoning victim had been exposed to a dose of 20 mg or more of dimethylnitrosamine per… CONTINUE READING

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