Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through Fas- and mitochondria-mediated pathways.

@article{Chen2013MethylatedAD,
  title={Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through Fas- and mitochondria-mediated pathways.},
  author={Yongqiang Chen and Jinjuan Liu and Bo Yuan and Chengliang Cao and Sheng Qin and Xiaoying Cao and Guangkai Bian and Zhe Wang and Jihong Jiang},
  journal={Molecular carcinogenesis},
  year={2013},
  volume={52 12},
  pages={
          983-96
        }
}
Actinomycin D (Act D), a well known of clinical antitumor drug, has been used for the treatment of some highly malignant tumors, however, the clinical application was limited by its extreme cytotoxicity. In the present study, we reported that methylated actinomycin D (mAct D), a novel actinomycin D analog isolated from Streptomyces sp. KLBMP 2541 in our previous study, could not only exert stronger inhibitory effects on several human cancer cells than Act D in dose- and time-dependent manner at… CONTINUE READING