Methylated TIMP-3 DNA in body fluids is an independent prognostic factor for gastric cancer.

@article{Yu2014MethylatedTD,
  title={Methylated TIMP-3 DNA in body fluids is an independent prognostic factor for gastric cancer.},
  author={Jiang-liu Yu and Ping Lv and Jing Han and Xin Zhu and L L Hong and Wang-Yu Zhu and Xin-bao Wang and Yi-chen Wu and Pei Li and Zhi-Qiang Ling},
  journal={Archives of pathology & laboratory medicine},
  year={2014},
  volume={138 11},
  pages={1466-73}
}
CONTEXT Fluid methylated DNA may be a suitable biomarker for cancer patients. OBJECTIVE To investigate whether circulating methylated tissue inhibitor of metalloproteinase 3 (TIMP-3) DNA in body fluids is a useful prognostic biomarker in gastric cancer (GC). DESIGN TIMP-3 methylation was detected by real-time methylation-specific polymerase chain reaction in tumor tissues, paired preoperative peritoneal washes (PPWs), and paired serum samples from 92 GC patients. RESULTS The frequency of… CONTINUE READING
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