Methylated HBHA Produced in M. smegmatis Discriminates between Active and Non-Active Tuberculosis Disease among RD1-Responders

@inproceedings{Delogu2011MethylatedHP,
  title={Methylated HBHA Produced in M. smegmatis Discriminates between Active and Non-Active Tuberculosis Disease among RD1-Responders},
  author={Giovanni Delogu and Teresa Chiacchio and Valentina Vanini and Ornella Butera and Gilda Cuzzi and Alessandra Bua and Paola Molicotti and Stefania Zanetti and Francesco Nicola Lauria and Susanna Grisetti and Nicola Magnavita and Giovanni Fadda and Enrico Girardi and Delia Goletti},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND A challenge in tuberculosis (TB) research is to develop a new immunological test that can help distinguish, among subjects responsive to QuantiFERON TB Gold In tube (QFT-IT), those who are able to control Mtb replication (remote LTBI, recent infection and past TB) from those who cannot (active TB disease). IFN-γ response to the Heparin-binding-hemagglutinin (HBHA) of Mtb has been associated with LTBI, but the cumbersome procedures of purifying the methylated and immunological active… CONTINUE READING