Methylated DNA-binding protein from human placenta recognizes specific methylated sites on several prokaryotic DNAs.

@article{Wang1986MethylatedDP,
  title={Methylated DNA-binding protein from human placenta recognizes specific methylated sites on several prokaryotic DNAs.},
  author={Richard Yuan-Hu Wang and Xiujuan Zhang and Rafiya Khan and Yanqiu Zhou and Leslie H Huang and M. Ehrlich},
  journal={Nucleic acids research},
  year={1986},
  volume={14 24},
  pages={9843-60}
}
Methylated DNA-binding protein (MDBP) from human placenta recognizes specific DNA sequences containing 5-methylcytosine (m5C) residues. Comparisons of binding of various prokaryotic DNAs to MDBP indicate that m5CpG is present in the recognition sites for this protein but is only part of the recognition sequence. Specific binding to MDBP was observed for bacteriophage XP12 DNA, which naturally contains approximately 1/3 of its residues as m5C, and for Micrococcus luteus DNA, M13mp8 replicative… CONTINUE READING

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