Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus

@article{Yu2015MethylatedBA,
  title={Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus},
  author={Ming Yu and Rachele M. O'Leary and Andrew M. Kaz and Shelli M. Morris and Kelly T Carter and Amitabh Chak and Apoorva Krishna Chandar and Joseph E. Willis and Helen R Moinova and Sanford D. Markowitz and Dean E. Brenner and Sharmila Anandabapasathy and Maria Westerhoff and Chao-Jen Wong and Nicholas J. Shaheen and Yanwen Chen and Jill S. Barnholtz-Sloan and William M. Grady},
  journal={Cancer Epidemiology, Biomarkers \& Prevention},
  year={2015},
  volume={24},
  pages={1890 - 1897}
}
Background: Barrett's esophagus (BE) is a preneoplastic condition in which normal esophageal squamous epithelium (SQ) is replaced by specialized intestinal metaplasia. It is the presumed precursor for esophageal adenocarcinoma (EAC) as well as the strongest risk factor for this cancer. Unfortunately, many patients with BE go undiagnosed under the current BE screening guidelines. The development of noninvasive and accurate BE detection assays could potentially identify many of these undiagnosed… 
Highly Discriminant Methylated DNA Markers for the Non‐endoscopic Detection of Barrett's Esophagus
BACKGROUND: Minimally invasive methods have been described to detect Barrett's esophagus (BE), but are limited by subjectivity and suboptimal accuracy. We identified methylated DNA markers (MDMs) for
Molecular Evolution of Metaplasia to Adenocarcinoma in the Esophagus
  • W. Grady, M. Yu
  • Biology, Medicine
    Digestive Diseases and Sciences
  • 2018
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B Barrett’s esophagus provides researchers with a unique model to characterize the process by which a carcinoma arises from its precursor lesion, and new insight is provided into the evolutionary forces underlying the molecular alterations seen in BE and EAC and into the molecular pathogenesis of EAC.
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It is ascertained that intestinal metaplasia partially recapitulates patterns of aberrant methylation of intestinal type of gastric cancer, independently of the H. pylori status, which supports the need to investigate the practical utilities of the quantification of DNA methylation in candidate genes as a marker for disease progression.
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The results suggest the implication of alterations in DNA methylation in gastric cardiac IM and highlight that HOXA5 hypermethylation may be a promising epigenetic biomarker, emphasizing the role of aberrant HOX a5 expression in the pathogenesis of gastric medical metaplasia.
CEBP FOCUS Barrett’s Esophagus and Esophageal Adenocarcinoma Biomarkers A C
Esophageal adenocarcinoma is a major cause of cancer-related morbidity and mortality in Western countries. The incidences of esophageal adenocarcinoma and its precursor Barrett’s esophagus have
Barrett's Esophagus and Esophageal Adenocarcinoma Biomarkers
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An updated overview of the molecular pathology of Barrett's esophagus and esophageal adenocarcinoma and emerging molecular biomarker assays, as well as the role of EDRN in biomarker discovery and validation, will be discussed.
Epigenetic alterations in the gastrointestinal tract: Current and emerging use for biomarkers of cancer.
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Epigenetic alterations have emerged as one of most robust classes of biomarkers and are the basis for a growing number of clinical tests for cancer screening and surveillance.
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The state-of-the-art technologies for early diagnosis and minimally invasive treatment of esophageal cancer using resection and ablation technologies supported by evidence from randomized controlled trials are reviewed.
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Evidence for the influence of environmental exposures on obesity and how epigenetic alterations may contribute to cancers that disproportionately affect minority populations exhibit disparities in incidence and mortality are summarized in this chapter.

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