Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease

@inproceedings{Matuschek2010MethylatedAA,
  title={Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease},
  author={Christiane Matuschek and Edwin Boelke and Guido M Lammering and P. A. Gerber and Matthias Peiper and Wilfried Budach and H{\"u}seyin Taskin and H B Prisack and Gisela Schieren and Klaus Orth and Hans Bojar},
  booktitle={European journal of medical research},
  year={2010}
}
BACKGROUND Tumor-related methylated DNA and circulating tumor cells (CTC) in the peripheral blood might be of prognostic importance in breast cancer. Thus, the aim of our study was to examine free methylated DNA and CTC in the blood from breast cancer patients and to correlate it with clinicopathological features known to influence prognosis. MATERIALS AND METHODS We prospectively obtained serum samples from 85 patients with breast cancer and 22 healthy volunteers. Sera were analysed by… CONTINUE READING
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