Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.

@article{McCullough2000MethylsubstitutedDC,
  title={Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.},
  author={Kevin J. McCullough and James E. Wood and Apurba K. Bhattacharjee and Yuxiang Dong and Dennis E. Kyle and Wilbur K. Milhous and Jonathan L. Vennerstrom},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 6},
  pages={1246-9}
}
Two tetramethyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15, 16-tetraoxadispiro[5.2.5.2]hexadecanes) 3 and 4 were designed as metabolically stable analogues of the dimethyl-substituted dispiro-1, 2,4,5-tetraoxane prototype WR 148999 (2). For a positive control we selected the sterically unhindered tetraoxane 5 (7,8,15, 16-tetraoxadispiro[5.2.5.2]hexadecane), devoid of any substituents. Tetraoxanes 3 and 4 were completely inactive in contrast to tetraoxanes 2 and 5. We hypothesize that the… CONTINUE READING

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